Aside from against ManCity, before he got injured. We were very good against ManCity with him on the pitch in a 4-3-3 with Cuadrado and Morata as RWF and LWF respectively.
The reason we look like $#@! the last couple matches with him, is because of 3-5-2 and partnering two non-creative, non-passing CFs up front, forcing Morata to play as an SS. Morata can play two positions well, CF and LWF. He's always been a decent wing forward, a la Ronaldo, being allowed freedom to roam in attack.
And Mandzukic is an excellent forward in a 4-3-3, and was very good playing between Morata and Cuadrado.
If it's 4-3-1-2 or 3-5-2 or first choice up front should be Morata-Dybala.... But in 4-3-3, Morata-Mandzukic-Cuadrado is excellent and should be rotated heavily with a Morata-Dybala-Cuadrado trio.