When you see a situation like this the mistake has already happened.
You can see in the picture below that Rabiot didn't work nearly hard enough to get under the ball. You also see from Bonucci's body position the he is toast if Mkhitaryan takes a touch to the left. Really difficult situation for a defender to be running 30m full tilt towards your own goal with a player running at you. I'm sure a better defender could have made a better effort to win the ball. However these are situations you want to avoid as a team. Having opposing forwards running at your defenders on an open field is a recipe for disaster.