Boy, it would be difficult. Onyewu for instance would not be a starter for us. Then there's players like Witsel, Kompany and Fellaini who are at least as good, but probably a lot better than the best the US has to offer.
And even still, the fact that it would even be a contest tells you that Americans don't care about FOOTBALL. You have no football culture whatsoever. It's a pity, I agree, but your national league IS a joke.