Made the same mistakes. Those comodo's take up FAR to much ammo.
What i did, was making a bigger backpack, so i could carry more for sales, sell whatever i had from herbs and stuff, get the bigger wallet etc.
The reason is simple. You need to unlock a few guns, and replenish the ammo. and be able to carry a decent amount of ammo.
that requires money, wich requires backpacks to carry shit, and the containers for the ammo size
Sniperrifle early with good scope is so handy.
You got these "whack that guy" missions. If you manage to kill off his escort of afar, its pretty easy to sneak in and knife the target.