I guess with Draxler, it the most natural thing to do would be to use Draxler and Dybala moving all the time and swichting positions between AM/winger/SS, with Morata as a very mobile CF moving sides to open space for Dybala/Draxler penetration.
This could work out naturally also...
Placing Mandzukic between these guys is the thing that gets a bit mindblogging to me, because it would force these kids to slightly adapt to new functions/roles.