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After playing one friendly game, i'm not that impressed with the game. Its pretty much the same as FM2005, with minor changes.
One thing i dont like about it, is while trying to offer your player to clubs. In FM2005, you could offer your players to clubs by adding the "suggested clubs" by your assistant. But in the FM2006, that option isnt available anymore. It has only one option i.e. "all human clubs". So its really annoying to get rid of players fast, untill someone's interested. For example in my case at the moment, Zlayeta is transfer listed, and he is wanted by 4/5 clubs, but the problem is that i cant offer him specifically to these 4/5 clubs untill they start the bidding.
Gladstone's stats are impressive.
A tip for everyone - Ballack, Cassano, Volpi, Diesler, Karimi, Anderson, Ze roberto and many more will be free the following year.
As soon as you start the game, offer a contract to Anderson. I was late and he already signed for Porto.