A mid of Inler, Pirlo, and Melo would be too static, me thinks, especially if Pirlo is a deep-lying central playmaker, like in Milan. It might work if Pirlo is in more of a trequartista role, infront of Melo and Inler and immediately behind the 3 up-front - that way he would be surrounded with more dynamic players but even then there is the question if Pirlo is dynamic enough himself for that role ... has a better chance of working out, though, I think.
Personally, I think Pirlo would work best in the midfield in a Xavi type of role i.e. as RM or LM - in front of the more defensive-minded back (presumably Lichtsteiner) - with possibly Inler in the center, Melo being sold and another midfielder coming in, who combines a midfield enforcer with creativity and dynamism and would make runs forward, without compromising the back too much. A perfect example is Seedorf under Ancelotti at Milan 5-6 years ago - he was the one who made possible the scheme with a relatively weak and slow player like Pirlo in the middle work well defensively, while at the same time Milan were pretty darn good going forward, considering Gattuso added only muscle to the team.
Problem is it is not easy at all finding a midfielder like that since most players out there are either muscle enforcer w/o much creativity or are technically sound, creative players but usually lightweight and not much of sound tackling in them.