Only if the billionaire owners back out/stop buying. They fund the whole show now, they are the ones circulating money, paying wages, bringing top players which increases interest and tv money spread throughout the league. As long as those guys are there and interested the league won't have problems in general.
The irony with Serie A is that Juve are actually spending more from an owner perspective in the poorer league, big markets and two €100m+ bailouts. It's not just the collapse of Parma and Lazio as money clubs, everyone is spending less, but you've taken Berlusconi, Moratti and Cragnotti away as big spenders, so the whole league suffers.