Do you even what the heck you are talking about? Honestly, your psuedo way to talk about how they would effect Pogba and Dybala is LAUGHABLE.
Isco is a creator on high technical level, the kind we or more like Allegri need (because I honestly prefer signing a wing forward over an AM, less predictable that way), yeah he holds on to the ball too long at times (he tries to play like a natural nr 10 way that doesnt exist in most of footie anymore sadly, except few teams like ours that litterally want a trequartista to carry the torch) but most of the time has satellite view understanding of his surroundings, enough to use his passing/dribbling through channels with purpose. Was the same in Malaga and whenever he dominated in youth Spain. A player who open things up and is unpredictable. Even as a marginalized 3rd fiddle role as in Real he creates and assists enough for the attackers quite a bit despite sporadic playing time and clear issues with consistency.
Felipe Anderson besides being NOWHERE near his talent is basically a speed merchant with good dribbling. He knows what to do when there's room ahead of him, blitz and win ground, but his decision making and ability to connect with others with ease is very much lacking most of this season and even at his best in last. Can become a very good winger, but the kind that doesnt have much football IQ and will commit the same type of moves all game long. Which is easier to understand why things go so badly for him this season, him and most of Lazio are off form (except Biglia, Candreva, on occasion Mauri etc), and his way of dealing with is battering his way into the defence with same runs and sulking when he doesnt learn from it. If opponents adapt to you (sophmore season in Serie A are toughest for players), or you have less space in counters, you try to re-discover yourself to become of some use. But instead become too much of a ghost compared to last season. Only Lazio player thats been more annoying to watch when I seen them is that serbian hack Sasa-Milinkovic, who sucks so damn much.