I'm really going to get it for this... but one notable EPL striker that I think could be very effective in Serie A is Peter Crouch.
Yes, him...
Not as a starting striker, but because he's so good in the air and hard to defend against due to his versatility and lanky nature. He could be a very effective supersub poacher if he had good service from guys like Camoranesi. He wouldn't be a very useful 90 minute player, because rough Italian defenses would wear him down.
Of course, he would never accept being a supersub... so its a non-starter. I like Van Persie too, when he's not hurt. Drogba is an arrogant ass, but the guy is effective... VERY effective.