Creatine is produced naturally in the liver Glycine+Arginine->ornithine and guanidinoacetate which is then methylated by S-adenosylmethionine to form creatine. Creatine travels from the liver to other tissues where it is converted to creatine phosphate. ATP phosphorylates creatine to form creatine phosphate. Muscle and brain contain large amounts of creatine phosphate. It provides a small reservoir of high-energy phosphate which can regenerate ATP from ADP. It plays a particularly important role in muscle during the early stages of exercise. After all the creatine is depleted muscle metabolism depends largely in glycogen. This is the reason loading muscles with creatine makes us feel stronger during the first sets.
Creatine later turns into creatinine and is excreted by the kidneys. The amount is proportional to body mass. So , doctors use creatinine as a measure for body mass and renal function. As far as I know, creatine has no effect on stretch receptors in muscles. Stretch receptors are sensors that produce "pain" when the muscles limit it's reached
Creatine later turns into creatinine and is excreted by the kidneys. The amount is proportional to body mass. So , doctors use creatinine as a measure for body mass and renal function. As far as I know, creatine has no effect on stretch receptors in muscles. Stretch receptors are sensors that produce "pain" when the muscles limit it's reached
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