I think that marchisio is a must in the middle as he will provide the midfield with a much needed drive and mobility through the middle. It is something that both tiago and poulsen cannot do, but they will provide more control.
The other option as i see it putting neddy in the middle next to any of the DMs and put gio in the starting line up. I don't think that Ranieri would even consider this option, i just hope that he doesn't start with tiago and poulsen as the midfield would be too static.
I wouldn't mind starting marchisio and tiago with brazzo on the right as he will be a more defensive option than Iaq, Amauri or even gio. He will provide more cover for the midfield.
Grygera is back so at least lets hope he plays well defensively.