Marchisio is not a DM, no. He is a box-to-box CM. What I'm saying is he can play in a 2-man midfield. Of course CM partners should complement each other. You wouldn't play Makelele and Mascherano together in a 4-4-2 nor Scholes and Xavi. England had problems fitting Gerrard and Lampard together so they moved Gerrard out wide and tried all kinds of things.
Marchisio--Vidal could work if we had particularly capable and creative wingers. For Juve, I'd say 4-3-3 with Vidal--Pirlo--Marchisio is the best option.
We'll see if Vidal--Pirlo works. It may, but Vidal will then not be the attacking threat he was with Leverkusen as he'd be forced to watch Pirlo's ass.