I can't really answer the first part of your question, my man. The only thing that I can think of is that they were trying to set up their passing game using he run, to try and negate the 49ers pass rush.
In regards to the 2nd sentence. In the Monday night win, the 49ers lost both their Pro Bowl Fullback and their starting right tackle who made the all rookie team last year to injuries, so they had to adjust their game plan somewhat, as their running game wasn't going to be as effective.
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The other thing
@JCK is that they are now starting their 4th and 5th Offensive tackles on their depth chart. A 2019 6th round pick at LT and an Undrafted free agent at RT.