The Benign Bosnian hasn't been working for 3 months, but hey, let's just start him. Perhaps, just magically, he will perform. A midfield 3 of Bentancur, Ramsey and Rabiot (yes, currently he's better than a shit Pjanic).
I'd start with De Ligt and Chiellini, or conserve Chiellini for our most important game of the season midweek, and start with De Ligt and Bonehead.
Also, I was being sarcastic when I called them big guns