If you are a frequent Pes player, I would say it defenitely is. I didnt think it would be prior when they said its gonna be same as 2020, and its pretty close to it, same engine, build, menues etc. But actual gameplay differences is although minor, is significant enough for me to be worth buying. Game is smoother, more responsive, slower passed, harder to control passes/shots etc. And this is changes they made for a carbon copy game of pes 2020, Konami with all their faults, dont fuck around when it comes tot he gameplay.
I expect pes2022 will be massive amount of changes considering its what they pooling all their time on, and it being for a new gen game.