He is very difficult to use. His best skill is finishing. But he's not a big #9 and he's not a great target.
If you want to amplify Dybala the most, you would play him as a #9 or with a big striker that dumps balls to him.
But if you want the best TEAM, it's tough to fit Dybala. It's been like this his whole career. You could play a 2 striker formation that is designed for him to find the most space and then defensively, you are defending with only 9 players instead of 10. So in the aggregate, maybe you're actually worse?
Is this a criticism of Dybala as a player or a criticism of his archetype? If he came up in the early 2000s, he would be much better off probably.