It shouldn't. My doctor believes it's because of the amount of Xanax and Citalopram I have to take to combat my Depression, that this came about. I'm on Warafrin right now until I can get it regulated. I've also cut down on the dose of Xanax that I take, but I MUST continue to take the Citalopram, if not, I'm an emotional mess. And if anyone tells me otherwise, even my father, I punch him in the face. Gotta love Gino Genesio