As far as this particular match, it was a joke. We missed 3 or 4 absolute 100% chances. Costa hit two posts. They didn't touch the ball in our box. You can't even evaluate this match really.
As far as the general team setup. It's still too dependent on Dybala. Again, I always say this, but it's not that easy to balance the team with Higuain and Dybala. You are basically playing two #9s which is not something any team does nowadays.
A lot of the offensive setup is to make space for Dybala to receive the ball and when he can't control a single thing, the team will look bad. The #10 is such an important position, it's basically the most important in this formation.
I don't want to be too reactionary or over-exaggerate the situation but I wonder sometimes how much better the team would be with a real #10. As far as the rest of the setup, it basically picks itself at this point. Cuadrado has to play because we defend with 8 and on top of it he has to baby sit whoever is at RB. The CMs are basically interchangeable outside of Pjanic. The LW position is the only spot where you can debate Mandzu, Costa or even Berna.
You can't play a one striker formation with Higuain/Dybala so Max has very little choice in how to setup the team.
And I've said this before also but the return of Howedes could be a massive boost. We can revert to our 3-4-3 hybrid that we used with Alves last year because Howedes can play that RB/CB spot. This is the only change I can think of that will make our team more "fluid" with these two #9s that we have to play.