4321 it should be:
Buffon
Llicht-Bonucci-Chiellini-Evra
Vidal-Marchisio-Pogba
Dybala-Morata
Mandzukic
Can easily be switched to 433 or 4312 by a simple sub. If one of our ST's need a break sub in Berardi/Pereyra and switch the formation.
Quite simple IMO. Gives us a huge flexibility.