The 24 teams that qualify are joined with 8 teams from the Champions League who finished at the 3rd position in the CL group.
The draw for the 2nd round takes the following rules into account:
a) Clubs from the same association must not be drawn against each other,
b) The 12 group-winners and the 4 best third-ranked teams in the Champions League group stage are drawn against the 12 group runners-up and the remaining third-ranked teams in the Champions League group stage,
c) The winners and runners-up of the same group cannot be drawn against each other,
d) Group-winners and the 4 best third-ranked in the Champions League group stage play the return leg at home.
So looking at the toughest we can get are totenham, valencia, benfica, shaktar donestk, basel, sevilla, lyon. Another trip to turkey could also happen with trabzonspor.