Let's be honest, if you're playing a 4-3-1-2 what do you prefer (while Marchisio is hurt)?
----Higuain-----Dybala-----
-----------James------------
-Pjanic-------------Khedira--
-----------Sturaro-----------
Just switch Khedira and Sturaro. Sturaro is not comfortable in that position. Khedira on the other hand has played this role many times, does it well too, no surprise as he's a fine midfielder.
But will any of these two actually stay injury free and fit?