Are you really asking? Most recently like two weeks ago when we drew Cesena 2-2. We could have gone ahead of Roma 11 points if we beat them.
There is no significant tradeoff, in my opinion. Marchisio ends up being as creative as Pirlo on most occasions because he is more mobile on the pitch, which leads to more opportunities to make a through pass. Pirlo has to rely a lot on long balls, and while he's a master, they don't often lead to a chance, and with Serie A teams packing their half with players his creative output becomes very limited more often than not.