Good news for Chiello, lets hope the same happens to Sandro, we really need him vs a team like Real. If he`s fit, I`d go with:
MattiaDS - Rugani - Chiellini - Asamoa
DCosta - Marchisio - Matuidi - Alex Sandro
Dybala
Higuain
If Sandro`s out or on bench, then Max would probably opt for additional midfielder instead of Mandzukic and 4-2-3-1 of some sorts - (a la Tottenham in Turin), also because we will once again start a game in CL with no attacking player on the bench.
MDS - Rugani - Chiellini - Asamoa
Marchisio
Khedira - Matuidi
DCosta - Higuain - Dybala
Wishful thinking, as we know that if all 4 of Costa, Mandzukic, Dybala and Higuain are match fit, they will all play.