Well Marchisio and Dybala missing sucks. But fuck it. Things aew like this and we should fight till the end.
Some thoughts for the game: Firstly, Rugani should not start. It's a very dangerous game that can go easily wrong with lack of experience. Secondly, this is the one game of the year (till now) that Sturaro definitely has to be in the starting 11. A 4-4-2 would be really fragile with only 2 people at the centre. On the other hand, a 4-3-1-2 would focus a lot on an unready Pereyra leaving out a very in form Cuadrado. And we need Cuadrado a lot in this game as he can make something out of nothing.
Personally I would go for a 4-3-3 Manchester city like approach. Morata or Pereyra on the left depending how much we want to defend and on how fit Mandzukic is. Sturaro, Khedira and Pogba in the centre and it starts to look not very bad..