They are different indeed just like all of the teams are different, yet they play against one another and compare.
EPL is totally different than Serie A but there's no way Italian league is a better one.
I don't think what to think about Serie A vs Bundesliga. Italian league is definitely less entertaining and more boring to watch. But there's way more competition in Serie A it can't even be compared. It's very hard to get points from Napoli, Roma, Lazio, Fiorentina. Let alone Inter and Milan. While in German there's Dortmund and that's it.