I won't be surprised if Max benches Cuadrado, moves Dybala more to the left and play Marchisio as a top of Khedira-Pjanic-Claudio triangle.
It would make no sense whatsoever so it would be very surprising
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Its logical Khedira plays with Pjanic at the moment
Pjanic talent is an immense boost for this formation which gets the best out of him.
But we need to adapt and learn the formation. Khedira's natural position is exactly that role next to Pjanic. So we'll play him for the time beeing to improve the rate at which our players master all the details of this 4231.
Later, Marchisio can be introduced for either Khedira or Pjanic. Or if Dybala is rotated, Pjanic moves to CAM and Marchisio hold the midfield with Khedira.