More than anything, I think it's imperative that we have pace in midfield to counter attack effectively. Last game, the trio of Marchisio, Sissoko and De Ceglie were superb.
Another option is Zebina as RB and Grygera on LB. De Ceglie in midfield.
Marchisio's back for this one, isn't he?
Camoranesi - Marchisio - Poulsen - DC
Amauri - Del Piero
This is the best "realistic" formation I can think of.