If it was up to me, I'd play Pjanic-Can and unleash all Dybala-Ronaldo-Mandzu-Berna.
At the end of the day Mario defends and pulls back as a defender and cover spaces when needed which is more than enough.
He already said he wont against Napoli he will go back to 4-3-3.
The lineup is pretty much predictable, only question is whether Dybala or Berna will start, most likely it'll be Berna.