I would go straight 3-5-2 against their 4-4-2.
3 CBs matchup better against 2 STs. Especially when one is Ronaldo.
I really, really hate the idea of trying to stop Ronaldo with a flat 4-4-2. Even if you can defend all the crosses with just 2 CBs and no DM, surely a ball will fall in the box and he will find it.
I greatly prefer 3 CBs and 1 DM vs. 2 CBs and 0 DM.
Rugani-Benatia-Chiellini
Marchisio