Do we play Lyon away right after this game?
If yes, I expect the biggest turnover so far into the season.
One of the CBs, Alves, Khedira are a lock. Possibly one of Dybala and Higuain, depending on how many minutes they will see during the break.
It could be interesting to rest Pjanic too, but I don't think it will be possible.
Away game vs Lyon is the most important match we'll have in the group stage. We really can't lose that game.