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Barca's defense is $#@!, and their midfield is nowhere near what it used to be. I expect them to score in both games, but so will we. It might come down to away goals. We have a proud home record to protect; the last European home game we lost was against Bayern in the Quarters, and that was back in 2013. Let's keep the trend going. I'm gonna say 2-1 home win, and 3-2 away loss.
I'd be tempted to deploy a 3-4-3, with BBC in defense (maybe Rugani instead of one of them), Cuadrado on the right, Sandro on the left, Pjanic and Marchisio in midfield, with Dybala and Mandzukic supporting Higuain. Depending on the result of the 1st game, we can even go 3-5-2 in the away leg, with Dani Alves starting.